Robert De Niro gained 60 pounds for his role as Jake LaMotta in Raging Bull; production was reportedly shut down for several months so he could bulk up and play the real-life boxer-turned-stand-up-comic in his later (larger) years.
Breaking Robert De Niro's weight-gain record, Vincent D'Onofrio gained a whopping 70 pounds in order to play overweight Marine recruit Private Leonard "Gomer Pyle" Lawrence in Full Metal Jacket.
Renée Zellweger gained 28 pounds for her role as singleton Bridget Jones in Bridget Jones's Diary. She then slimmed down, before piling on the pounds again for the sequel, Bridget Jones: The Edge of Reason.
Charlize Theron gained 30 pounds in order to play real-life prostitute-turned-serial killer Aileen Wuornos in Monster, while her co-star Christina Ricci gained about 10 pounds to play the role of her lover Selby Wall.
Jared Leto gained 67 pounds by drinking pints of microwaved ice cream laced with olive oil and soy sauce for his role as the Catcher in the Rye-obsessed killer of John Lennon, Mark David Chapman, in Chapter 27.
Matt Damon ate pizzas and burgers and drank dark beers in order to gain 30 pounds for his role as "doughy" corporate executive-turned-whistleblower Mark Whitacre in The Informant!
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